Dr. Mark Trombetta

Dr. Mark Trombetta


Mark Trombetta, MD, FACR, is nationally and internationally known for his work in making radiation treatments easier, less toxic and more effective for cancer patients.

A radiation oncologist at Allegheny Health Network’s Cancer Institute, Dr. Trombetta has led the health network in the development of numerous new treatment modalities and innovations.

A longtime leader at the AHN Cancer Institute, he currently serves as System Director of Clinical Programs, Department of Radiation Oncology, and leads the department’s breast cancer programs.

Dr. Trombetta actively participates in research and has authored more than 50 publications, edited two textbooks, and served on the editorial boards of five journals. He has also been appointed to numerous national committees including the Breast Committee of the NRG Oncology group.

In addition to being an accomplished researcher, Dr. Trombetta is a skilled and compassionate clinician, reaching treatment decisions collaboratively with patients and tailoring treatment to each individual’s needs and values. He has been recognized by his peers as a \“Best Doctor\” multiple times.

In 2010, Dr. Trombetta was inducted as a Fellow in the American College of Radiology (ACR), an honor given to only 10 percent of ACR members. ACR Fellows demonstrate a history of service to the College, organized radiology, teaching, or research.

Among the highlights of his research career, he led a long-term study finding that treating a breast cancer recurrence with a combination of radioactive seed implantation and tumor excision rather than with mastectomy, or whole breast removal, is an effective approach for many women. The findings added to a growing body of knowledge suggesting that mastectomy can sometimes be avoided when treating women with a breast cancer recurrence.

In collaboration with other AHN researchers, Dr. Trombetta is also working to develop a gene therapy technique that could give new hope to cancer patients suffering from severe dry mouth, a common and devastating effect of radiation therapy. The research is funded by a $1.7 million National Institutes of Health grant.

Dr. Trombetta was recently selected as an editor of the book \“Brachytherapy; An International Perspective,\” described as \“the first truly comprehensive and complete textbook of brachytherapy…Each chapter incorporates the American and European guidelines and the text has been written from both perspectives by many of the most noted global experts in the field.\”

Brachytherapy is an advanced cancer treatment in which radioactive seeds are placed in or near the tumor, delivering a high dose of radiation to the tumor while avoiding surrounding healthy tissues. Dr. Trombetta is board certified through the American Board of Radiology with a sub-specialization in Brachytherapy.

Dr. Trombetta serves as Professor of Radiation Oncology at Drexel University College of Medicine. He is a member of the ACR, American Society of Radiation Oncology, American Society of Clinical Oncology, and the American Society of Breast Disease. Dr. Trombetta earned his medical degree from Hahnemann University (now Drexel University) in 1985.


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